The ACC kicks off its Week 3 with a Thursday night affair in Louisville as the Cardinals host No. 11 Clemson.

On Friday, defending ACC champion No. 9 Florida State travels to Boston College to take on the Eagles.

In early Saturday action, two ACC-Big Ten matchups will take place in the Tar Heel State at 12: 00 p.m. North Carolina hosts Illinois and Duke welcomes No. 23 Northwestern.

Miami hosts Nebraska at 3:30 p.m. in a battle of historical powers. The Hurricanes and Cornhuskers have met 11 times before, with the Big Red Machine holding a slight, 6-5 edge over the Canes.

Also at 3:30 p.m., No. 8 Notre Dame hosts No. 14 Georgia Tech. The Fighting Irish lost starting quarterback Malik Zaire last week for the season, and will turn to backup DeShone Kizer against the Yellow Jackets.

The rest of the Week 2 ACC football schedule is listed below, as well as picks and previews.

Week 3 ACC Football Schedule

Note: All times Eastern.

Thursday, September 17

7:30 PM No. 11 Clemson at Louisville, ESPN, WATCH ESPN

Friday, September 18

8:00 PM No. 9 Florida State at Boston College, ESPN, WATCH ESPN

Saturday, September 19

12:00 PM Illinois at North Carolina, ESPN2, WATCH ESPN

12:00 PM Wake Forest at Army, CBSSN

12:30 PM Central Michigan at Syracuse, ESPN3

12:30 PM No. 23 Northwestern at Duke, ESPN3

3:30 PM Nebraska at Miami (FL), ABC, ESPN2, WATCH ESPN

3:30 PM William & Mary at Virginia, ESPN3

3:30 PM Virginia Tech at Purdue, ESPNU, WATCH ESPN

3:30 PM No. 14 Georgia Tech at No. 8 Notre Dame, NBC

7:00 PM NC State at Old Dominion

8:00 PM Pittsburgh at Iowa, Big Ten Network

Week 3 ACC Football Picks & Previews

• No. 11 Clemson at Louisville
• No. 9 Florida State at Boston College
• Illinois at North Carolina
• Wake Forest at Army
• Central Michigan at Syracuse
• No. 23 Northwestern at Duke
• Nebraska at Miami (FL)
• William & Mary at Virginia
• Virginia Tech at Purdue
• No. 14 Georgia Tech at No. 8 Notre Dame
• NC State at Old Dominion
• Pittsburgh at Iowa

MORE: College Football Bowl Projections After Week 2