Pac-12 football picks and spreads for Week 10 of the 2015 season. This week’s most intriguing matchup comes by way of Seattle between the Utah Utes and Washington Huskies. The Huskies defense has been excellent this season, and will try to slow down Utes QB Travis Wilson and company. Can Utah stay in the lead for the Pac-12 South, or will the Huskies hand the Utes their second loss? Scroll down for this week’s Pac-12 picks.

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Stanford vs. Colorado

Date: Saturday, November 7

Kickoff: 1:00 p.m. ET

Venue: Folsom Field

After escaping Pullman last week with a narrow win over Washington State, the Cardinal now face a Colorado defense that can’t stop much of anything. Do-it-all Stanford running back Christian McCaffrey as Stanford cruises to an easy win.

Pick: Stanford

Spread: Stanford -16

For final score prediction, check out our Stanford vs. Colorado game preview.

Arizona State vs. Washington State

Date: Saturday, November 7

Kickoff: 3:30 p.m. ET

Venue: Martin Stadium

Cougars QB Luke Falk has started to prosper under Coach Mike Leach, and the Washington State offense is one of the nation’s most explosive units. Both defenses will have their hands full in this track meet that’ll end in WSU’s favor. 

Pick: Washington State

Spread: Washington State -2.5

For final score prediction, check out our Arizona State vs. Washington State game preview.

UCLA vs. Oregon State

Date: Saturday, November 7

Kickoff: 4:30 p.m. ET

Venue: Reser Stadium

Bruins QB Josh Rosen has the advantage of throwing to wide receivers Jordan Payton and Thomas Duarte, and will face a Beavers defense that hasn’t had much success in keeping anyone out of the end zone. That trend will continue as UCLA runs away for a three score win.

Pick: UCLA

Spread: UCLA -17.5

For final score prediction, check out our UCLA vs. Oregon State game preview.

Utah vs. Washington

Date: Saturday, November 7

Kickoff: 7:30 p.m. ET

Venue: Husky Stadium

This one is going to be a close, low-scoring affair. Washington will have the home crowd and momentum after pasting Arizona last week, 49-3. Huskies defense will come up with more key stops than the Utes. 

Pick: Washington

Spread: Washington -1

For final score prediction, check out our Utah vs. Washington game preview.

Oregon vs. California

Date: Saturday, November 7

Kickoff: 10:30 p.m. ET

Venue: Autzen Stadium

Now that QB Vernon Adams is back for the Ducks, the offense has taken its production up another notch, something they were missing earlier in the season. But can the Ducks defense, which has allowed more passing TDs than any FBS team in the country, stop Bears QB Jared Goff? Not likely, but Oregon will outpace Cal in an old-fashioned, Pac-12 track meet. 

Pick: Oregon

Spread: Oregon -4.5

For final score prediction, check out our Oregon vs. California game preview.

USC vs. Arizona

Date: Saturday, November 7

Kickoff: 10:30 p.m. ET

Venue: Los Angeles Memorial Coliseum

The running trio of Tre Madden, Justin Davis and Ronald Jones has been solid since Clay Helton took over as interim coach. Add in the improved play of QB Cody Kessler, and it smells disaster for a Wildcats defense that gives up an average of 40 points per game in Pac-12 play. USC is going to look like USC in this one. 

Pick: USC

Spread: USC -17.5

For final score prediction, check out our USC vs. Arizona game preview.